MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain.

MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain.

Generating spatially controlled, non-destructive changes in the interstitial spaces of the brain has a host of potential clinical applications, including enhancing the delivery of therapeutics, modulating biological features within the tissue microenvironment, altering fluid and pressure dynamics, a...

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Bibliographic Details
Main Authors: David S Hersh, Pavlos Anastasiadis, Ali Mohammadabadi, Ben A Nguyen, Sijia Guo, Jeffrey A Winkles, Anthony J Kim, Rao Gullapalli, Asaf Keller, Victor Frenkel, Graeme F Woodworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5802894?pdf=render

Internet

http://europepmc.org/articles/PMC5802894?pdf=render

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