DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

Lung cancer is one of the deadliest cancers worldwide due to chemoresistance in patients with late-stage disease. Quinoline derivatives show biological activity against HIV, malaria, bacteriuria, and cancer. DFIQ is a novel synthetic quinoline derivative that induces cell death in both in vitro and...

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Bibliographic Details
Main Authors: Hurng-Wern Huang, Yung-Ding Bow, Chia-Yih Wang, Yen-Chun Chen, Pei-Rong Fu, Kuo-Feng Chang, Tso-Wen Wang, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
non-small-cell lung cancer (NSCLC)
quinoline derivative
DFIQ
ROS
apoptosis
lysosome accumulation
Online Access:https://www.mdpi.com/2072-6694/12/5/1348

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https://www.mdpi.com/2072-6694/12/5/1348

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