Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart

Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart

The causal genetic underpinnings of congenital heart diseases, which are often complex and multigenic, are still far from understood. Moreover, there are also predominantly monogenic heart defects, such as cardiomyopathies, with known disease genes for the majority of cases. In this study, we identi...

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Bibliographic Details
Main Authors: Emilie Auxerre-Plantié, Tanja Nielsen, Marcel Grunert, Olga Olejniczak, Andreas Perrot, Cemil Özcelik, Dennis Harries, Faramarz Matinmehr, Cristobal Dos Remedios, Christian Mühlfeld, Theresia Kraft, Rolf Bodmer, Georg Vogler, Silke R. Sperling
Format: Article
Language:English
Published: The Company of Biologists 2020-12-01
Series:Disease Models & Mechanisms
Subjects:
congenital heart disease
cardiomyopathy
cg14964
myomesin
candidate gene
Online Access:http://dmm.biologists.org/content/13/12/dmm045377

Internet

http://dmm.biologists.org/content/13/12/dmm045377

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