Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic <i>Pyrococcus</i> <i>furiosus</i> Phosphoglucose Isomerase

Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic <i>Pyrococcus</i> <i>furiosus</i> Phosphoglucose Isomerase

The cupin-type phosphoglucose isomerase (PfPGI) from the hyperthermophilic archaeon <i>Pyrococcus furiosus</i> catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. We investigated PfPGI using protein-engineering bioinformatics tools to select functionall...

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Bibliographic Details
Main Authors: Kalyanasundaram Subramanian, Karolina Mitusińska, John Raedts, Feras Almourfi, Henk-Jan Joosten, Sjon Hendriks, Svetlana E. Sedelnikova, Servé W. M. Kengen, Wilfred R. Hagen, Artur Góra, Vitor A. P. Martins dos Santos, Patrick J. Baker, John van der Oost, Peter J. Schaap
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biomolecules
Subjects:
Protein engineering
Comulator
cupin phosphoglucose isomerase
<i>Pyrococcus furiosus</i>
solvent access
Online Access:https://www.mdpi.com/2218-273X/9/6/212

Internet

https://www.mdpi.com/2218-273X/9/6/212

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