Oxidation of Cefalexin by Permanganate: Reaction Kinetics, Mechanism, and Residual Antibacterial Activity

The oxidation of cefalexin (CFX), a commonly used cephalosporin antibiotic, was investigated by permanganate (PM) in water. Apparent second-order rate constant of the reaction between CFX and PM was determined to be 12.71 ± (1.62) M−1·s−1 at neutral pH. Lowe...

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Bibliographic Details
Main Authors: Yajie Qian, Pin Gao, Gang Xue, Zhenhong Liu, Jiabin Chen
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/23/8/2015