Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling

Reproducible inference of transcription factor footprints in ATAC-seq and DNase-seq datasets using protocol-specific bias modeling

Abstract Background DNase-seq and ATAC-seq are broadly used methods to assay open chromatin regions genome-wide. The single nucleotide resolution of DNase-seq has been further exploited to infer transcription factor binding sites (TFBSs) in regulatory regions through footprinting. Recent studies hav...

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Bibliographic Details
Main Authors: Aslıhan Karabacak Calviello, Antje Hirsekorn, Ricardo Wurmus, Dilmurat Yusuf, Uwe Ohler
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
ATAC-seq
DNase-seq
Footprinting
Bias correction
Reproducibility
Online Access:http://link.springer.com/article/10.1186/s13059-019-1654-y

Internet

http://link.springer.com/article/10.1186/s13059-019-1654-y

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