Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism

Adipose TG lipase (ATGL) catalyzes the rate-limiting step in TG hydrolysis in most tissues. We have shown that hepatic ATGL preferentially channels hydrolyzed FAs to β-oxidation and induces PPAR-α signaling. Previous studies have suggested that liver FA binding protein (L-FABP) transports FAs from l...

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Bibliographic Details
Main Authors: Kuok Teong Ong, Mara T. Mashek, Nicholas O. Davidson, Douglas G. Mashek
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Journal of Lipid Research
Subjects:
peroxisome proliferator-activated receptor-α
β-oxidation
liver fatty acid binding protein
adipose triglyceride lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375003

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http://www.sciencedirect.com/science/article/pii/S0022227520375003

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