Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation

Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation

Abstract Corneal neovascularization (CNV) causes higher-order aberrations, corneal edema, ocular inflammation, and corneal transplant rejection, thereby decreasing visual acuity. In this study, we investigated the effects of topical administration of the kappa opioid receptor agonist nalfurafine (TR...

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Bibliographic Details
Main Authors: Hurramhon Shokirova, Takenori Inomata, Tsuyoshi Saitoh, Jun Zhu, Kenta Fujio, Yuichi Okumura, Ai Yanagawa, Keiichi Fujimoto, Jaemyoung Sung, Atsuko Eguchi, Maria Miura, Ken Nagino, Kunihiko Hirosawa, Mizu Kuwahara, Yasutsugu Akasaki, Hiroshi Nagase, Akira Murakami
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88118-6

Internet

https://doi.org/10.1038/s41598-021-88118-6

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