Loosening of Side-Chain Packing Associated with Perturbations in Peripheral Dynamics Induced by the D76N Mutation of β<sub>2</sub>-Microglobulin Revealed by Pressure-NMR and Molecular Dynamic Simulations

Loosening of Side-Chain Packing Associated with Perturbations in Peripheral Dynamics Induced by the D76N Mutation of β<sub>2</sub>-Microglobulin Revealed by Pressure-NMR and Molecular Dynamic Simulations

&#946;<sub>2</sub>-Microglobulin (&#946;<sub>2</sub>m) is the causative protein of dialysis-related amyloidosis, and its D76N variant is less stable and more prone to aggregation. Since their crystal structures are indistinguishable from each other, enhanced amyloidog...

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Bibliographic Details
Main Authors: Kazumasa Sakurai, Ryosuke Tomiyama, Takuma Shiraki, Yasushige Yonezawa
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
High pressure experiment
NMR
β<sub>2</sub>-microglobulin
MD simulation
amyloid fibril
Online Access:https://www.mdpi.com/2218-273X/9/9/491

Internet

https://www.mdpi.com/2218-273X/9/9/491

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