The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Abstract Background Traumatic brain injury (TBI) is a common neurotrauma leading to brain dysfunction and death. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) hold promise in the treatment of TBI. However, their efficacy is modest due to low survival and differentiation under the ha...

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Bibliographic Details
Main Authors: Fangxia Guan, Tuanjie Huang, Xinxin Wang, Qu Xing, Kristyn Gumpper, Peng Li, Jishi Song, Tao Tan, Greta Luyuan Yang, Xingxing Zang, Jiewen Zhang, Yuming Wang, Yunlei Yang, Yashi Liu, Yanting Zhang, Bo Yang, Jianjie Ma, Shanshan Ma
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Stem Cell Research & Therapy
Subjects:
Neuroprotection
Mitsugumin 53
Stem cells
Traumatic brain injury
PI3K-Akt-GSK3β
Online Access:https://doi.org/10.1186/s13287-019-1433-4

Internet

https://doi.org/10.1186/s13287-019-1433-4

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