Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

Glycosyltransferases (GTs) are prevalent across the tree of life and regulate nearly all aspects of cellular functions. The evolutionary basis for their complex and diverse modes of catalytic functions remain enigmatic. Here, based on deep mining of over half million GT-A fold sequences, we define a...

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Bibliographic Details
Main Authors: Rahil Taujale, Aarya Venkat, Liang-Chin Huang, Zhongliang Zhou, Wayland Yeung, Khaled M Rasheed, Sheng Li, Arthur S Edison, Kelley W Moremen, Natarajan Kannan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
glycosyltransferase
GT evolution
donor prediction
GT phylogeny
common core
machine learning
Online Access:https://elifesciences.org/articles/54532

Internet

https://elifesciences.org/articles/54532

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