A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

A Three-Dimensional Alzheimer’s Disease Cell Culture Model Using iPSC-Derived Neurons Carrying A246E Mutation in PSEN1

Alzheimer’s disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory and neuronal loss, caused mainly by extracellular deposition of amyloid-β (Aβ) and intracellular accumulation of hyperphosphorylated tau protein, primarily in areas implicated in memory...

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Bibliographic Details
Main Authors: Mercedes A. Hernández-Sapiéns, Edwin E. Reza-Zaldívar, Ricardo R. Cevallos, Ana L. Márquez-Aguirre, Karlen Gazarian, Alejandro A. Canales-Aguirre
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
3D cell culture
Alzheimer’s disease
iPSC-derived neurons
disease modeling
personalized therapy
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00151/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00151/full

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