Acute depletion of CTCF rewires genome-wide chromatin accessibility

Acute depletion of CTCF rewires genome-wide chromatin accessibility

Abstract Background The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute depletion of CTCF globally reduces chromatin interac...

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Bibliographic Details
Main Authors: Beisi Xu, Hong Wang, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Biology
Subjects:
ATAC-seq
Auxin-induced degron
Chromatin accessibility
CTCF
Transcription factor
Proteomics
Online Access:https://doi.org/10.1186/s13059-021-02466-0

Internet

https://doi.org/10.1186/s13059-021-02466-0

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