Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival

Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival

Increased expression of Yes-associated protein-1 (YAP1) was shown to correlate with reduced survival in breast cancer (BC) patients. However, the exact mechanism of YAP1 regulation in BC cells remains ambiguous. Genomic sequence search showed that the promoter region of the YAP1 gene contains CpG Is...

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Bibliographic Details
Main Authors: Jibran Sualeh Muhammad, Maha Guimei, Manju Nidagodu Jayakumar, Jasmin Shafarin, Aisha Saleh Janeeh, Rola AbuJabal, Mohamed Ahmed Eladl, Anu Vinod Ranade, Amjad Ali, Mawieh Hamad
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Epigenetics
DNA methylation
Estrogen
Yes-associated protein-1 gene
Carcinogenesis
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301706

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http://www.sciencedirect.com/science/article/pii/S1476558620301706

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