Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death

Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death

Vps35 (vacuolar protein sorting 35) is a key component of retromer that consists of Vps35, Vps26, and Vps29 trimers, and sortin nexin dimers. Dysfunctional Vps35/retromer is believed to be a risk factor for development of various neurodegenerative diseases. <i>Vps35<sup>Neurod6</sup&g...

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Bibliographic Details
Main Authors: Yang Zhao, Fulei Tang, Daehoon Lee, Wen-Cheng Xiong
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
Vps35
retromer complex
neurodegeneration
gliosis
Online Access:https://www.mdpi.com/1422-0067/22/16/8394

Internet

https://www.mdpi.com/1422-0067/22/16/8394

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