A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding region comprising an expanded ferredoxin-like fol...

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Bibliographic Details
Main Authors: Sunbin Liu, Sina Mozaffari-Jovin, Jan Wollenhaupt, Karine F Santos, Matthias Theuser, Stanislaw Dunin-Horkawicz, Patrizia Fabrizio, Janusz M Bujnicki, Reinhard Lührmann, Markus C Wahl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
small nuclear ribonucleoprotein particle
pre-mRNA splicing
protein–RNA interaction
X-ray crystallography
Online Access:https://elifesciences.org/articles/07320

Internet

https://elifesciences.org/articles/07320

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