Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

Background: Ischemia reperfusion injury (IRI) plays a major role in solid organ transplantation. The length of warm ischemia time is critical for the extent of tissue damage in renal IRI. In this experimental study we hypothesized that local release of labile heme in renal tissue is triggered by the...

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Bibliographic Details
Main Authors: Li Wang, Vijith Vijayan, Mi-Sun Jang, Anja Thorenz, Robert Greite, Song Rong, Rongjun Chen, Nelli Shushakova, Igor Tudorache, Katja Derlin, Pooja Pradhan, Kukuh Madyaningrana, Nodir Madrahimov, Jan Hinrich Bräsen, Ralf Lichtinghagen, Cees van Kooten, Markus Huber-Lang, Hermann Haller, Stephan Immenschuh, Faikah Gueler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
ischemia reperfusion injury
AKI
HO-1
C5aR
C3aR
complement
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02975/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02975/full

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