Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.

Morphogenetic defects underlie Superior Coloboma, a newly identified closure disorder of the dorsal eye.

The eye primordium arises as a lateral outgrowth of the forebrain, with a transient fissure on the inferior side of the optic cup providing an entry point for developing blood vessels. Incomplete closure of the inferior ocular fissure results in coloboma, a disease characterized by gaps in the infer...

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Bibliographic Details
Main Authors: Jennifer C Hocking, Jakub K Famulski, Kevin H Yoon, Sonya A Widen, Cassidy S Bernstein, Sophie Koch, Omri Weiss, FORGE Canada Consortium, Seema Agarwala, Adi Inbal, Ordan J Lehmann, Andrew J Waskiewicz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5862500?pdf=render

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http://europepmc.org/articles/PMC5862500?pdf=render

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