The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.

The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme.

Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United States. GBM is characterized by extensive angiogenesis induced by vascular growth factors and cytokines. The transcription of these growth factors and cytokines is regulated by the Hypoxia-Inducible-Factor-1(H...

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Bibliographic Details
Main Authors: Enfeng Wang, Chunyang Zhang, Navatha Polavaram, Fengming Liu, Gang Wu, Mark A Schroeder, Julie S Lau, Debabrata Mukhopadhyay, Shi-Wen Jiang, Brian Patrick O'Neill, Kaustubh Datta, Jinping Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900478?pdf=render

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http://europepmc.org/articles/PMC3900478?pdf=render

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