Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods.

Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events. The time-point when the CD4+ count is assumed to change potentially biases effect estimates but methods used to estimate this are infrequently reported.This stu...

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Bibliographic Details
Main Authors: Katharina Kranzer, James J Lewis, Richard G White, Judith R Glynn, Stephen D Lawn, Keren Middelkoop, Linda-Gail Bekker, Robin Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3219676?pdf=render