cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

FADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constitutively lack these molecules die at an early embryonic age, whereas tissue-specific constitutive deletion of FADD or caspase-8 results in inflammatory skin disease caused by increased necroptosis. The function...

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Bibliographic Details
Main Authors: Diana Panayotova-Dimitrova, Maria Feoktistova, Michaela Ploesser, Beate Kellert, Mike Hupe, Sebastian Horn, Roman Makarov, Federico Jensen, Stefan Porubsky, Astrid Schmieder, Ana Claudia Zenclussen, Alexander Marx, Andreas Kerstan, Peter Geserick, You-Wen He, Martin Leverkus
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005585

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http://www.sciencedirect.com/science/article/pii/S2211124713005585

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