Methylation and Acetylation Enhanced the Antidiabetic Activity of Some Selected Flavonoids: In Vitro, Molecular Modelling and Structure Activity Relationship-Based Study

Methylation and Acetylation Enhanced the Antidiabetic Activity of Some Selected Flavonoids: In Vitro, Molecular Modelling and Structure Activity Relationship-Based Study

Flavonoids have been reported to exert antihyperglycemic effects and have potential to enhance the current therapy options against type 2 diabetes mellitus. However, the structure activity relationships (SAR) studies of flavonoids against this disease have not been thoroughly comprehended. Hence, in...

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Bibliographic Details
Main Authors: Qamar Uddin Ahmed, Murni Nazira Sarian, Siti Zaiton Mat So'ad, Jalifah Latip, Solachuddin Jauhari Arief Ichwan, Nurlaili Najmie Hussein, Muhammad Taher, Alhassan Muhammad Alhassan, Hanisuhana Hamidon, Sharida Fakurazi
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Biomolecules
Subjects:
flavonoids
type 2 diabetes mellitus
RIN-5F pancreatic cells
3T3-L1 pre-adipocytes
adipokines
SAR
molecular docking
Online Access:https://www.mdpi.com/2218-273X/8/4/149

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https://www.mdpi.com/2218-273X/8/4/149

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