Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.
Loss of retinoblastoma (Rb) tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward genetic screen and positional cloning, we identified and characterized a zebrafish ubiq...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3020934?pdf=render |