Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.

Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.

Loss of retinoblastoma (Rb) tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward genetic screen and positional cloning, we identified and characterized a zebrafish ubiq...

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Bibliographic Details
Main Authors: Yesenia Ríos, Shlomo Melmed, Shuo Lin, Ning-Ai Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3020934?pdf=render

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