BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4+ T Cells

BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4+ T Cells

Tuberculosis (TB) is a major global public health problem causing significant mortality and morbidity. In addition to ~10.4 million cases of active TB annually, it is estimated that about two billion people are latently infected with Mycobacterium tuberculosis (Mtb), the causative agent of TB. React...

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Bibliographic Details
Main Authors: Harindra D. Sathkumara, Saparna Pai, Michel de Jesús Aceves-Sánchez, Natkunam Ketheesan, Mario Alberto Flores-Valdez, Andreas Kupz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
BCG
vaccines
CD4 T cells
reactivation
BCGΔBCG1419c
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00532/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00532/full

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