Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT

Polyphyllin Ⅲ-Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT

Ferroptosis, which is characterized by the accumulation of intracellular iron and subsequent lipid peroxidation, is a newly discovered form of regulated cell death and plays an important role in tumor suppression. Herein, we showed that Polyphyllin III, which is a major saponin extracted from Paris...

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Bibliographic Details
Main Authors: Yulu Zhou, Jingjing Yang, Cong Chen, Zhaoqing Li, Yongxia Chen, Xun Zhang, Linbo Wang, Jichun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
Polyphyllin III
ACSL4
ferroptosis
xCT
KLF4
breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.670224/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.670224/full

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