Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells.

Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells.

Deregulation of platelet-derived growth factor (PDGF) signaling is a hallmark of malignant glioma. Two alternatively spliced PDGF-A mRNAs have been described, corresponding to a long (L) and a short (S) isoform of PDGF-A. In contrast to PDGF-A(S), the PDGF-A(L) isoform has a lysine and arginine rich...

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Bibliographic Details
Main Authors: Inga Nazarenko, Anna Hedrén, Hanna Sjödin, Abiel Orrego, Johanna Andrae, Gijs B Afink, Monica Nistér, Mikael S Lindström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072383?pdf=render

Internet

http://europepmc.org/articles/PMC3072383?pdf=render

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