Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin.

Huntingtin (Htt) is a 350 kD intracellular protein, ubiquitously expressed and mainly localized in the cytoplasm. Huntington's disease (HD) is caused by a CAG triplet amplification in exon 1 of the corresponding gene resulting in a polyglutamine (polyQ) expansion at the N-terminus of Htt. Produ...

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Bibliographic Details
Main Authors: Bin Huang, Tanja Lucas, Claudia Kueppers, Xiaomin Dong, Maike Krause, Alexander Bepperling, Johannes Buchner, Hans Voshol, Andreas Weiss, Bertran Gerrits, Stefan Kochanek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370734?pdf=render

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http://europepmc.org/articles/PMC4370734?pdf=render

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