mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate...

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Main Authors:	Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, Ivan Topisirovic
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11127

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spelling	doaj-3b23e374915e42abafd814b872f5dd1d2021-05-11T10:41:06ZengNature Publishing GroupNature Communications2041-17232016-04-017111510.1038/ncomms11127mTORC1 and CK2 coordinate ternary and eIF4F complex assemblyValentina Gandin0Laia Masvidal1Marie Cargnello2Laszlo Gyenis3Shannon McLaughlan4Yutian Cai5Clara Tenkerian6Masahiro Morita7Preetika Balanathan8Olivier Jean-Jean9Vuk Stambolic10Matthias Trost11Luc Furic12Louise Larose13Antonis E. Koromilas14Katsura Asano15David Litchfield16Ola Larsson17Ivan Topisirovic18Lady Davis Institute, SMBD JGH, McGill UniversityDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska InstitutetLady Davis Institute, SMBD JGH, McGill UniversityDepartments of Biochemistry and Oncology, Schulich School of Medicine & Dentistry, Western University, LondonLady Davis Institute, SMBD JGH, McGill UniversityLady Davis Institute, SMBD JGH, McGill UniversityLady Davis Institute, SMBD JGH, McGill UniversityDepartment of Biochemistry, McGill UniversityBiomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Cancer Program, Monash UniversityUPMC Univ Paris 06, CNRS-UMR8256and the Department of Medical Biophysics, Princess Margaret Cancer Centre, University Health Network, University of TorontoMRC Protein Phosphorylation and Ubiquitylation Unit, University of DundeeBiomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Cancer Program, Monash UniversityDepartment of Medicine, Polypeptide Laboratory, McGill University and The Research Institute of McGill University Health CentreLady Davis Institute, SMBD JGH, McGill UniversityDivision of Biology, Molecular Cellular and Developmental Biology Program, Kansas State UniversityDepartments of Biochemistry and Oncology, Schulich School of Medicine & Dentistry, Western University, LondonDepartment of Oncology-Pathology, Science for Life Laboratory, Karolinska InstitutetLady Davis Institute, SMBD JGH, McGill UniversityTernary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate cell proliferation.https://doi.org/10.1038/ncomms11127
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic
spellingShingle	Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic mTORC1 and CK2 coordinate ternary and eIF4F complex assembly Nature Communications
author_facet	Valentina Gandin Laia Masvidal Marie Cargnello Laszlo Gyenis Shannon McLaughlan Yutian Cai Clara Tenkerian Masahiro Morita Preetika Balanathan Olivier Jean-Jean Vuk Stambolic Matthias Trost Luc Furic Louise Larose Antonis E. Koromilas Katsura Asano David Litchfield Ola Larsson Ivan Topisirovic
author_sort	Valentina Gandin
title	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_short	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_full	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_fullStr	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_full_unstemmed	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
title_sort	mtorc1 and ck2 coordinate ternary and eif4f complex assembly
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-04-01
description	Ternary complex (TC) and eIF4F complex assembly are rate-limiting steps in translation initiation that are regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway. Here the authors show that the protein kinases mTORC1 and CK2 coordinate TC and eIF4F complex assembly through eIF2β to stimulate cell proliferation.
url	https://doi.org/10.1038/ncomms11127
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mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

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