mTOR as a central regulator of lifespan and aging [version 1; peer review: 3 approved]

by David Papadopoli, Karine Boulay, Lawrence Kazak, Michael Pollak, Frédérick A. Mallette, Ivan Topisirovic, Laura Hulea
Published 2019-07-01

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin

by David Papadopoli, Oro Uchenunu, Ranveer Palia, Nabila Chekkal, Laura Hulea, Ivan Topisirovic, Michael Pollak, Julie St-Pierre
Published 2021-04-01

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

by Yuri V Svitkin, Akiko Yanagiya, Alexey E Karetnikov, Tommy Alain, Marc R Fabian, Arkady Khoutorsky, Sandra Perreault, Ivan Topisirovic, Nahum Sonenberg
Published 2013-01-01

Distinct translational control in CD4+ T cell subsets.

by Eva Bjur, Ola Larsson, Ekaterina Yurchenko, Lei Zheng, Valentina Gandin, Ivan Topisirovic, Shui Li, Carston R Wagner, Nahum Sonenberg, Ciriaco A Piccirillo
Published 2013-05-01

The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

by Mohamed Moustafa-Kamal, Thomas J. Kucharski, Wissal El-Assaad, Yazan M. Abbas, Valentina Gandin, Bhushan Nagar, Jerry Pelletier, Ivan Topisirovic, Jose G. Teodoro
Published 2020-10-01

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

by Palaniraja Thandapani, Jingwen Song, Valentina Gandin, Yutian Cai, Samuel G Rouleau, Jean-Michel Garant, Francois-Michel Boisvert, Zhenbao Yu, Jean-Pierre Perreault, Ivan Topisirovic, Stéphane Richard
Published 2015-08-01

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation.

by Victoria E B Hipolito, Jacqueline A Diaz, Kristofferson V Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Saric, Shannon Mclaughlan, Ola Larsson, Ivan Topisirovic, Roberto J Botelho
Published 2019-12-01

FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation

by Denise Cook, Erin Nuro, Emma V. Jones, Haider F. Altimimi, W. Todd Farmer, Valentina Gandin, Edith Hanna, Ruiting Zong, Alessandro Barbon, David L. Nelson, Ivan Topisirovic, Joseph Rochford, David Stellwagen, Jean-Claude Béïque, Keith K. Murai
Published 2014-11-01

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

by Valentina Gandin, Laia Masvidal, Marie Cargnello, Laszlo Gyenis, Shannon McLaughlan, Yutian Cai, Clara Tenkerian, Masahiro Morita, Preetika Balanathan, Olivier Jean-Jean, Vuk Stambolic, Matthias Trost, Luc Furic, Louise Larose, Antonis E. Koromilas, Katsura Asano, David Litchfield, Ola Larsson, Ivan Topisirovic
Published 2016-04-01

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

by Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Published 2020-07-01

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

by Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Published 2021-07-01

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

by Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Étienne Huot, Frédérick A. Mallette
Published 2016-09-01

Translational control of breast cancer plasticity

by Michael Jewer, Laura Lee, Matthew Leibovitch, Guihua Zhang, Jiahui Liu, Scott D. Findlay, Krista M. Vincent, Kristofferson Tandoc, Dylan Dieters-Castator, Daniela F. Quail, Indrani Dutta, Mackenzie Coatham, Zhihua Xu, Aakshi Puri, Bo-Jhih Guan, Maria Hatzoglou, Andrea Brumwell, James Uniacke, Christos Patsis, Antonis Koromilas, Julia Schueler, Gabrielle M. Siegers, Ivan Topisirovic, Lynne-Marie Postovit
Published 2020-05-01

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

by Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Published 2021-06-01

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

by Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
Published 2019-07-01

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

by Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic, Ernesto Guccione
Published 2020-07-01