Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia

Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia

Neonatal encephalopathy (NE) is a significant cause of morbidity and mortality. Persistent inflammation and activation of leukocytes mediate brain injury in NE. The standard of care for NE, therapeutic hypothermia (TH), does not improve outcomes in nearly half of moderate to severe cases, resulting...

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Bibliographic Details
Main Authors: Mary Isabel O'Dea, Lynne Kelly, Ellen McKenna, Ashanty M. Melo, Megan Ni Bhroin, Tim Hurley, Angela T. Byrne, Gabrielle Colleran, Claudine Vavasseur, Afif El-Khuffash, Jan Miletin, John Murphy, Fionnuala Hickey, Eleanor J. Molloy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pediatrics
Subjects:
neuroimmunology
monocytes
neutrophils
neonatal encephalopathy
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2020.598724/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2020.598724/full

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