Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1–RIPK3-Dependent Pathway in Mice

Catecholamine Surges Cause Cardiomyocyte Necroptosis via a RIPK1–RIPK3-Dependent Pathway in Mice

Background: Catecholamine surges and resultant excessive β-adrenergic stimulation occur in a broad spectrum of diseases. Excessive β-adrenergic stimulation causes cardiomyocyte necrosis, but the underlying mechanism remains obscure. Necroptosis, a major form of regulated necrosis mediated by RIPK3-c...

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Bibliographic Details
Main Authors: Penglong Wu, Mingqi Cai, Jinbao Liu, Xuejun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
necroptosis
RIPK1
RIPK3
isoproterenol
cardiomyocyte
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.740839/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.740839/full

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