Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

We examined the blood–brain barrier (BBB) function in methylazoxymethanol acetate (MAM)-treated rats, a model of human developmental brain malformations. We found aberrant vessels morphology and serum albumin leakage in the heterotopic (malformed) hippocampus; these changes were associated with a si...

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Bibliographic Details
Main Authors: Nicola Marchi, Giovanna Guiso, Silvio Caccia, Massimo Rizzi, Barbara Gagliardi, Francesco Noé, Teresa Ravizza, Stefania Bassanini, Stefano Chimenti, Giorgio Battaglia, Annamaria Vezzani
Format: Article
Language:English
Published: Elsevier 2006-12-01
Series:Neurobiology of Disease
Subjects:
Blood–brain barrier
Epilepsy
Methylazoxymethanol acetate
Multidrug transport proteins
P-glycoprotein
Pharmacoresistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001781

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http://www.sciencedirect.com/science/article/pii/S0969996106001781

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