A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate.

A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidate.

The circumsporozoite protein (CSP) of Plasmodium falciparum is a major surface protein, which forms a dense coat on the sporozoite's surface. Preclinical research on CSP and clinical evaluation of a CSP fragment-based RTS, S/AS01 vaccine have demonstrated a modest degree of protection against P...

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Bibliographic Details
Main Authors: Amy R Noe, Diego Espinosa, Xiangming Li, Jordana G A Coelho-Dos-Reis, Ryota Funakoshi, Steve Giardina, Hongfan Jin, Diane M Retallack, Ryan Haverstock, Jeffrey R Allen, Thomas S Vedvick, Christopher B Fox, Steven G Reed, Ramses Ayala, Brian Roberts, Scott B Winram, John Sacci, Moriya Tsuji, Fidel Zavala, Gabriel M Gutierrez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4172688?pdf=render

Internet

http://europepmc.org/articles/PMC4172688?pdf=render

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