Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3

Spinocerebellar ataxia (SCA) types 1, 2, 3, 6, 7, and 17 as well as Huntington’s disease are a group of neurodegenerative disorders caused by expanded CAG repeats encoding a long polyglutamine (polyQ) tract in the respective proteins. Evidence has shown that the accumulation of intranuclear and cyto...

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Main Authors: Kuo-Hsuan Chang, Wan-Ling Chen, Li-Ching Lee, Chih-Hsin Lin, Pin-Jui Kung, Te-Hsien Lin, Yi-Ci Wu, Yih-Ru Wu, Yi-Chun Chen, Guey-Jen Lee-Chen, Chiung-Mei Chen
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2013/471659