Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal p...

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Bibliographic Details
Main Authors: Chelsia Qiuxia Wang, Vaidehi Krishnan, Lavina Sierra Tay, Desmond Wai Loon Chin, Cai Ping Koh, Jing Yuan Chooi, Giselle Sek Suan Nah, Linsen Du, Bindya Jacob, Namiko Yamashita, Soak Kuan Lai, Tuan Zea Tan, Seiichi Mori, Ichiro Tanuichi, Vinay Tergaonkar, Yoshiaki Ito, Motomi Osato
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005300

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http://www.sciencedirect.com/science/article/pii/S2211124714005300

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