Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation

Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation

The Hippo pathway restricts organ size during development and its inactivation plays a crucial role in cancer. Yes-associated protein (YAP) and its paralog transcriptional coactivator with PSD-95/Dlg/ZO-1 (PDZ)-binding motif (TAZ) are transcription co-activators and effectors of the Hippo pathway me...

Full description

Bibliographic Details
Main Authors: Xinyan Ji, Lihua Song, Li Sheng, Anhui Gao, Yang Zhao, Shixun Han, Yuchao Zhang, Chu Zhu, Simeng Zhao, Zhe Wang, Bohan Xu, Li Li, Jia Li, Ninghua Tan, Bin Zhao
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
hippo pathway
YAP
TAZ
RA-V
cancer
organ size
protein synthesis
Online Access:https://www.mdpi.com/2072-6694/10/11/449

Internet

https://www.mdpi.com/2072-6694/10/11/449

Similar Items