2’, 5’-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway

2’, 5’-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway

Background: 2’, 5’-oligoadenylate synthetase 2 (OAS2) has been known as an antiviral interferon-stimulated gene (ISG). However, the role of OAS2 on Zika virus (ZIKV) replication is still unknown. In this study, we sought to explore the effect of OAS2 on ZIKV replication and its underlying mechanism....

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Bibliographic Details
Main Authors: Xinzhong Liao, He Xie, Shilin Li, Haiyan Ye, Shuang Li, Kai Ren, Yujia Li, Min Xu, Wenyu Lin, Xiaoqiong Duan, Chunhui Yang, Limin Chen
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
OAS2
ZIKV replication
IFNβ
Jak/STAT signaling pathway
Online Access:https://www.mdpi.com/1999-4915/12/4/418

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https://www.mdpi.com/1999-4915/12/4/418

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