Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody

Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody

Since cell nucleus is one of the most vulnerable compartments, the maximum therapeutic effect from a variety of locally acting agents, such as photosensitizers, alfa-emitters, Auger electron emitters, will be expected when they get there. Therefore, the targeted delivery of these agents into the nuc...

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Bibliographic Details
Main Authors: Tatiana S. Karyagina, Alexey V. Ulasov, Tatiana A. Slastnikova, Andrey A. Rosenkranz, Tatiana N. Lupanova, Yuri V. Khramtsov, Georgii P. Georgiev, Alexander S. Sobolev
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
affibody
cancer
epidermal growth factor receptors
modular nanotransporters
nuclear targeting
targeted drug delivery
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00176/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00176/full

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