Forced degradation of gliquidone and development of validated stability-indicating HPLC and TLC methods

Forced degradation studies of gliquidone were conducted under different stress conditions. Three degradates were observed upon using HPLC and TLC and elucidated by LC-MS and IR. HPLC method was performed on C18 column using methanol-water (85:15 v/v) pH 3.5 as a mobile phase with isocratic mode at 1...

Full description

Bibliographic Details
Main Authors: Mohamed Refaat El-ghobashy, Ali Mohamed Yehia, Aya Helmy Helmy, Nadia Fayek Youssef
Format: Article
Language:English
Published: Universidade de São Paulo 2018-11-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300603&lng=en&tlng=en