Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites

Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as other important cellular processes. HDACs ar...

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Bibliographic Details
Main Authors: Jessica A. Engel, Amy J. Jones, Vicky M. Avery, Subathdrage D.M. Sumanadasa, Susanna S. Ng, David P. Fairlie, Tina S. Adams, Katherine T. Andrews
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Plasmodium falciparum
Trypanosoma brucei
Malaria
African sleeping sickness
Histone
HDAC inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320715000123

Internet

http://www.sciencedirect.com/science/article/pii/S2211320715000123

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