Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse

Abstract The maximum value of the first derivative of the invasively measured left ventricular (LV) pressure (+ dP/dtmax or P′) is often used to quantify LV contractility, which in mice is limited to a single terminal study. Thus, determination of P′ in mouse longitudinal/serial studies requires a g...

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Bibliographic Details
Main Authors: Jorge Enrique Tovar Perez, Jesus Ortiz-Urbina, Celia Pena Heredia, Thuy T. Pham, Sridhar Madala, Craig J. Hartley, Mark L. Entman, George E. Taffet, Anilkumar K. Reddy
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79866-y