Correcting nucleotide-specific biases in high-throughput sequencing data

Correcting nucleotide-specific biases in high-throughput sequencing data

Abstract Background High-throughput sequence (HTS) data exhibit position-specific nucleotide biases that obscure the intended signal and reduce the effectiveness of these data for downstream analyses. These biases are particularly evident in HTS assays for identifying regulatory regions in DNA (DNas...

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Bibliographic Details
Main Authors: Jeremy R. Wang, Bryan Quach, Terrence S. Furey
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Bioinformatics
Subjects:
Epigenomics
Bias correction
DNase-seq
ATAC-seq
ChIP-seq
FAIRE-seq
Online Access:http://link.springer.com/article/10.1186/s12859-017-1766-x

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http://link.springer.com/article/10.1186/s12859-017-1766-x

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