NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation

NPC1161B, an 8-Aminoquinoline Analog, Is Metabolized in the Mosquito and Inhibits Plasmodium falciparum Oocyst Maturation

Malaria is a major global health threat, with nearly half the world’s population at risk of infection. Given the recently described delayed clearance of parasites by artemisinin-combined therapies, new antimalarials are needed to facilitate the global effort toward elimination and eradication. NPC11...

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Bibliographic Details
Main Authors: Timothy Hamerly, Rebecca E. Tweedell, Bernadette Hritzo, Vincent O. Nyasembe, Babu L. Tekwani, N. P. Dhammika Nanayakkara, Larry A. Walker, Rhoel R. Dinglasan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
Plasmodium
NPC1161B
malaria
8-aminoquinoline
transmission-blocking
metabolite analysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01265/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01265/full

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