The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis
Abstract Background Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it is not clear how formate induces pyrimidine synthesis. Methods Here we...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
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| Series: | Cancer & Metabolism |
| Online Access: | http://link.springer.com/article/10.1186/s40170-020-00228-3 |