Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

Design and synthesis of multi-target directed 1,2,3-triazole-dimethylaminoacryloyl-chromenone derivatives with potential use in Alzheimer's disease

Abstract To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a new series of 1,2,3-triazole-chromenone derivatives were designed and synthesized based on the multi target-directed ligands approach. The in vitro biological activities included acetylcholinesterase (A...

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Bibliographic Details
Main Authors: Hajar Karimi Askarani, Aida Iraji, Arezoo Rastegari, Syed Nasir Abbas Bukhari, Omidreza Firuzi, Tahmineh Akbarzadeh, Mina Saeedi
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Chemistry
Subjects:
Aβ aggregation
Biometal chelator
BuChE inhibitor
Chromenones
Neuroprotectivity
1,2,3-triazole
Online Access:http://link.springer.com/article/10.1186/s13065-020-00715-0

Internet

http://link.springer.com/article/10.1186/s13065-020-00715-0

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