Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate.
Depending on the species and the lymphoid organ, activation-induced cytidine deaminase (AID) expression triggers diversification of the rearranged immunoglobulin (Ig) genes by pseudo V (psiV) gene- templated gene conversion or somatic hypermutation. To investigate how AID can alternatively induce re...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2004-07-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC449846?pdf=render |