Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

The exact implication of innate immunity in granuloma formation and irreversible lung fibrosis remains to be determined. In this study, we examined the lung inflammatory and fibrotic responses to silica in MyD88-knockout (KO) mice. In comparison to wild-type (WT) mice, we found that MyD88-KO animals...

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Bibliographic Details
Main Authors: Sandra Lo Re, Giulia Giordano, Yousof Yakoub, Raynal Devosse, Francine Uwambayinema, Isabelle Couillin, Bernard Ryffel, Etienne Marbaix, Dominique Lison, François Huaux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4106757?pdf=render

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http://europepmc.org/articles/PMC4106757?pdf=render

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