Methylation patterns in serum DNA for early identification of disseminated breast cancer

Methylation patterns in serum DNA for early identification of disseminated breast cancer

Abstract Background Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We hypothesized that cell-free DNAme markers could indicate disseminated b...

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Bibliographic Details
Main Authors: Martin Widschwendter, Iona Evans, Allison Jones, Shohreh Ghazali, Daniel Reisel, Andy Ryan, Aleksandra Gentry-Maharaj, Michal Zikan, David Cibula, Johannes Eichner, Marianna Alunni-Fabbroni, Julian Koch, Wolfgang J. Janni, Tobias Paprotka, Timo Wittenberger, Usha Menon, Benjamin Wahl, Brigitte Rack, Harri Lempiäinen
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Genome Medicine
Subjects:
Cell-free DNA
DNA methylation
Serum DNA
Breast cancer
Early diagnosis
Personalized treatment
Online Access:http://link.springer.com/article/10.1186/s13073-017-0499-9

Internet

http://link.springer.com/article/10.1186/s13073-017-0499-9

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