Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration.

Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration.

Rats expressing a transgenic polycystic kidney disease (PKD) gene develop photoreceptor degeneration and subsequent vasoregression, as well as activation of retinal microglia and macroglia. To target the whole neuroglialvascular unit, neuro- and vasoprotective Erythropoietin (EPO) was intraperitonea...

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Bibliographic Details
Main Authors: Stephanie Busch, Aimo Kannt, Matthias Kolibabka, Andreas Schlotterer, Qian Wang, Jihong Lin, Yuxi Feng, Sigrid Hoffmann, Norbert Gretz, Hans-Peter Hammes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4094460?pdf=render

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http://europepmc.org/articles/PMC4094460?pdf=render

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